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  • Background: Cellular prion undergoes α-secretase cleavage, yielding N1. We examined whether N1 protects against Aβ monomers and oligomers.

    Results: N1 protects against Aβ monomers and oligomers prepared from APP-London-expressing human cells and Alzheimer disease-affected brains.

    Conclusion: N1 could protect from Aβ-associated toxicity at the early asymptomatic phase of Alzheimer disease.

    Significance: These data emphasize the cross-talk between PrPc and βAPP catabolites.

    Keywords: Alzheimer Disease, Amyloid, p53, Prions, Secretases, Aβ Oligomers, N1 Fragment, sAPPα

    Abstract

    In physiological conditions, both β-amyloid precursor protein (βAPP) and cellular prion (PrPc) undergo similar disintegrin-mediated α-secretase cleavage yielding N-terminal secreted products referred to as soluble amyloid precursor protein-α (sAPPα) and N1, respectively. We recently demonstrated that N1 displays neuroprotective properties by reducing pdependent cell death both in vitro and

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    Lake anoxia, primary production and algal community shifts in response to rapid climate changes during the Late-Glacial

    Stan Jonah Schouten, Noé Raymond Marie Marcel Schmidhauser, Martin Grosjean, Andrea Lami, Petra Boltshauser-Kaltenrieder, Jacqueline F. N. van Leeuwen, Hendrik Vogel, and Petra Zahajská

    EGUsphere, ,,

    Preprint under review for BG(discussion: open, 0 comments)

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    Can atmospheric chemistry deposition schemes reliably simulate stomatal ozone flux across global land covers and climates?

    Tamara Emmerichs, Abdulla Al Mamun, Lisa Emberson, Huiting Mao, Leiming Zhang, Limei Ran, Clara Betancourt, Anthony Wong, Gerbrand Koren, Giacomo Gerosa, Min Huang, and Pierluigi Guaita

    EGUsphere, ,,

    Preprint under review for BG(discussion: open, 0 comments)

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    13 Feb

    Toward a typology of river functioning: a comprehensive study of POM composition at multi-rivers scale 

    Florian Ferchiche, Camilla Liénart, Karine Charlier, Jonathan

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  • Stromae

    Belgian musician and producer (born )

    In this Dutch name, the surname is van Haver, not Haver.

    Musical artist

    Paul van Haver (Dutch pronunciation:[ˈpʌulvɑnˈɦaːvər]; born 12 March ), better known by his stage name Stromae (French pronunciation:[stʁɔmaj]),[1] fryst vatten a Belgian singer, rapper, songwriter and music producer. He fryst vatten best known for his music, which is a blend of hip-hop and electronic music styles. Stromae came to wide public attention in with his song "Alors on danse" (from the album Cheese), which became a number one in several europeisk countries. In , his second skiva Racine carrée was a commercial success, selling two million copies in France and yielding chart-topping singles "Papaoutai" and "Formidable".[2]

    Early life

    [edit]

    Paul van Haver was born in Brussels and raised in the city's Laken district, to a Tutsi father from Rwanda, Pierre Rutare, and a Flemish mother, Miranda van Haver.[3][4&